FATE OF LENTINAN (ANTITUMOR POLYSACCHARIDE) II : Fate of Methyl Lentinan in Rats
نویسندگان
چکیده
منابع مشابه
Antitumor effect of polysaccharide lentinan on MH-134 ascites hepatoma in C3H/He mice.
Lentinan inhibited the proliferation of MH-134 ascites hepatoma transplanted subcutaneously. The best result occurred when 1 mg-2 mg/kg of lentinan was administered for 10 consecutive days from the eighth day after tumor transplantation. Tumor proliferation was 33% inhibited as measured by the average tumor diameter. The average survival (days) when chemotherapy with mitomycin-C (MMC), 5-FU and...
متن کاملEvaluation of lentinan effects on cytochrome P450 activity in rats by a cocktail method
Objective(s): In this study, a cocktail of probe drugs was used to assess whether lentinan could influence the activities of rat enzymes CYP3A4, CYP2D6, CYP1A2, CYP2C19, and CYP2C9 in vivo. Materials and Methods: Fourteen days after intraperitoneal injection of lentinan, rats were given an oral dose of a cocktail solution containing phenacetin, tolbutamide, omeprazole, metoprolol, and midazolam...
متن کاملIn vitro inhibitory effects of lentinan on rat glioma cells
This study aimed to evaluate the inhibitory effect of lentinan on the growth of rat C6 glioma cells in vitro. After C6 cells were treated with lentinan for 24, 48 and 72 h respectively, cell activity was detected using MTT assay. After the cells were conducted Annexin V/PI double staining or PI single staining, apoptosis and cell cycle were detected by a flow cytometry. The activities of C6 cel...
متن کاملDepression of hepatic microsomal enzyme systems by lentinan in mice.
Studies were performed to determine the effects of an immunopotentiating agent, lentinan, on the hepatic drug-metabolizing enzymes in mice. Lentinan was injected twice a day for two days, and the enzyme activities were determined 12 hr after the last injection of lentinan. A lentinan dose of over 0.25 mg/kg was required to cause a significant decrease (20-40%) in the hepatic microsomal aminopyr...
متن کاملRetinoic Acid Determines the Fate of Spermatogonia
In this review, we aim to examine the effect of extrinsic and intrinsic factors on spermatogenesis process taking into account a complex signaling pathway. Primarily, it is suggested that retinoic acid (RA) has a vital function in spermatogenesis process and it is considered to be essential for completion of spermatogonia into mature spermatozoa. In the present review, the key effects of retino...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: The Journal of Toxicological Sciences
سال: 1980
ISSN: 0388-1350,1880-3989
DOI: 10.2131/jts.5.supplement_73